Endocrine Abstracts

Background: Foetus is protected from high quantities of steroids by placental enzyme 11BHSD2. It converts steroids to inactive form (dexamethasone and betamethasone are exceptions). Exposure to high steroids for long time could saturate the enzyme. Maternal steroid use carries a theoretical risk for neonatal adrenal insufficiency (AI). The evidence remains controversial and most NICUs don’t check for AI in those infants. Two units in south Yorkshire recom...

17 β-Hydroxysteroid Dehydrogenase Type 3 (17β-HSD3) deficiency is an autosomal recessive condition causing 46, XY disorder of sexual development (DSD). The enzyme is responsible for converting of Δ4-Androstenedione (A) to testosterone (T) in testicles. Affected individuals may present with abnormalities of the external genitalia at birth or during childhood and teenage years with virilisation or primary amenorrhea. The aim of this case series is to review the cl...

This case report delves into the intriguing connection between Kallmann syndrome and cardiomyopathy in a 62-year-old male who presented with new atrial fibrillation (AF) with rapid ventricular response and signs of fluid overload. Despite being a known case of Kallmann syndrome, the emergence of severe impaired left ventricular systolic dysfunction (LVSD) added a distinctive layer to the clinical scenario. Cardiomyopathy screenings for common causes like sarcoidosis, amyloidos...

Case History: A 71-year-old man with well controlled hypertension and left eye blindness due to congenital toxoplasma chorioretinitis presented to his GP with worsening headache. Initial CT head revealed a massive left parasellar lesion (32*25*36 mm) with suprasellar extension. Gadolinium-enhanced MRI revealed large cystic sellar mass, marked chiasmal compression and total encasement of Left carotid artery. 48 hours after MRI he was admitted acute severe right abdominal pain. ...

Introduction: Hypothyroid myopathy with moderate elevation of muscle enzymes is not uncommon. However rhabdomyolysis and acute renal failure due hypothyroidism is rare and only few cases have reported. We describe a patient with rhabdomyolysis due to primary hypothyroidism.Case report: A 45-year-old male was admitted with 6 weeks history of generalised muscle weakness. He described his gait as ‘walking like a drunk’ in the absence of alcohol. H...

Adrenal incidentalomata are a common finding on cross-sectional imaging of the abdomen. Further assessment is required to differentiate benign adrenal masses from adrenocortical carcinomas and hormone-secreting tumours. Phaeochromocytomas are rare catecholamine-secreting tumours arising from chromaffin cells of the adrenal medulla. They classically present with symptoms and signs of catecholamine excess including headache, sweating, hypertension and tachycardia. However, with ...

During the past year and a half during the Covid pandemic it has been noted that cases of abnormal thyroid functions post Covid infection rises and few case report published related to thyroiditis. For this we want to present one of our own patient who had Covid 19 infection in January 2020 with good recovery and after that she had symptoms of hyperthyroidism including palpitation weight loss and heat intolerance. It was confirmed with undetectable TSH and high T4 of 30. She w...

Background: The worldwide type 2 diabetes mellitus (T2DM) prevalence is increasing dramatically. Inflammation is involved in the pathogenesis of T2DM and development of insulin resistance. Lack of diabetic control is associated with alteration in the endocrine milieu and various health sequalae’s. The aim of this research was to assess if uncontrolled T2DM is associated with increased serum levels of inflammatory cytokines and growth factors when compared with controlled ...

Introduction: Current NICE guidelines recommend that children and young people with Type 1 Diabetes Mellitus (T1DM) should aim for a target HbA1c ≤48 mmol/mol (6.5%) to reduce the risk of long-term complications. The National Paediatric Diabetes Audit (NPDA) shows that the number of young people under the paediatric diabetes service with HbA1c >75 mmol/mol at this District General Hospital has been consistently and significantly above both the North West and national ave...

Introduction: In obesity and overweight, inflammation is associated with a progressive infiltration of immune cells causing cytokine secretion into adipose tissue. Objective. Evaluation of adipocytokines derived from adipose tissue and immune cells (adiponectin, resistin, TNF-α and IL-6). Materials and methods. 150 adults divided up in 3 groups; obese, overweight and controls. Adipocytokines (adiponectin, resistin, TNF-α and IL-6) were quantified by ELISA, serum insu...